Erasmus Summer Programme
Erasmus Summer Lectures [ESP64]
August 21, 2017
Erasmus MC, Querido Lecture Room
In these lectures timely topics in study design of epidemiologic and clinical studies will be addressed. Four renowned researchers will address advanced study design issues in a seminar format.
Moderator Professor Arfan Ikram, MD PhD
Monday August 21
Cardiovascular Disease in Women: Overturning Conventional Wisdom
The unisex approach to cardiovascular disease has been challenged. Evolving knowledge regarding gender dimorphism in disease pathophysiology, prevalence, symptom manifestation, and prognosis is emerging. The new evidence has given rise to the debate regarding the relative contribution of large versus small vessel disease in ischemic syndromes among women and men. Gender-related differences in cardiovascular disease are increasingly being linked to the greater microvascular dysfunction in women.
Maryam Kavousi, MD, PhD, FESC
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
Tuesday August 22
Epidemiology of kidney disease
Chronic kidney disease (CKD) contributes to the global burden of disease. It is estimated that one out of ten people have some degree of kidney disease. The aim of this lecture is to provide insight in the global epidemiology of CKD. In addition, this lecture aims to show how epidemiological research can identify determinants of CKD and how CKD connects to and accelerates cardiovascular disease. Finally, this lecture will also cover aspects of clinical nephrology, including equations used to estimate kidney function and the importance of albuminuria and dietary composition for risk classification and as targets for intervention.
Ewout Hoorn, MD PhD
Department of Internal Medicine, Division of Nephrology & Transplantation, Erasmus University Medical Center, Rotterdam, the Netherlands
Wednesday August 23
Setting up a population-based cohort in India: methodological challenges and innovative solutions
Population-based cohort studies in developing countries face, not only funding challenges, but also several methodological challenges which threaten their validity. Factors which may introduce selection bias in sample are both internal (altruism, motivation, health beliefs, culture) as well as external (limited health insurance, distance from the medical site, traffic conditions, transport facilities and others). Factors which threaten validity of measurements are social desirability bias, lack of culturally appropriate instruments, lack of education-free measuring tools, difference in rural-urban context and others. This lecture will describe the experience of how the barriers were overcome to successfully establish a cohort study with a rural and urban sample in and near Delhi, India.
Professor Kameshwar Prasad, MD, DM, MMSc, FRCP(Edin), FAMS
Professor & Head, Department of Neurology & Director, Clinical Epidemiology Unit, All India Institute of Medical Sciences, New Delhi, India
Thursday August 24
Translational research in asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) are two highly prevalent chronic airway diseases, causing substantial morbidity and mortality worldwide. Epidemiologic studies in the Rotterdam Study (RS) and other population-based cohorts have provided estimates of the prevalence and incidence of asthma and COPD in middle-aged and older populations. Moreover, epidemiologic research in the RS has demonstrated the occurrence of multiple co-morbidities in subjects with COPD, such as cardiovascular diseases, cerebrovascular diseases, osteoporosis and frailty. Since the current therapies of asthma and COPD are purely symptomatic and thus do not impact the natural course of the disease, better insights into the pathogenesis are warranted. Genetic epidemiologic studies of lung function measurements and COPD have elucidated many novel genetic loci implicated in disease pathogenesis. Through translational research these novel insights might lead to novel therapeutic targets.
Professor Guy Brusselle, MD PhD FERS
Professor of Respiratory Medicine, Department of Respiratory Medicine, Ghent University Hospital, Belgium
Professor of Epidemiology of Respiratory Diseases, Departments of Epidemiology and Respiratory Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
The Erasmus Summer Lectures are open without registration or fee for participants of the Erasmus Summer Programme, the NIHES programmes, employees of the Erasmus University Medical Center and public at large.
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