Erasmus Summer Programme Courses

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Case-control Studies [ESP40]

Course highlights

EC points




Course days

Monday to Friday (5 mornings)


Prof. Moyses Szklo

Course fee

€ 740


Erasmus MC, Rotterdam NL




Knowledge of basic epidemiology and basic biostatistics.


  • Methodology
  • Clinical Epidemiology
  • Clinical Research
  • Epidemiology

Course Materials

Online, download instructions will be sent in August by e-mail.

Recommended books:

Epidemiology: beyond the Basics by M. Szklo and F. Javier Nieto. ISBN: 076374722x. Published: Sudbury, Mass; Jones and Barlett. C2004

Case-Control studies; design, conduct, analysis by James. J. Schlesselman, with contributions by Paul D. Stolley. ISBN: 019502933x Published: New York: Oxford Univ. Press, C1982

Epidemiologic Reviews Volume 16. #1: John Hopkins Univ, C1994

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Detailed information about this course:


Faculty: Prof. Moyses Szklo, MD PhD

The course will provide an introduction to the design and analysis of case-control studies. Topics to be covered include case-based case-control, nested case-control and case-cohort designs, selection of cases and controls, the parameter measured by the odds ratio as a function of control selection, matched and unmatched strategies, confounding and common biases, and evaluation of additive and multiplicative interactions in case-control studies. These topics will be discussed in the context of the case-control design as a special way to analyze cohort data. In addition, a discussion of adjustment approaches appropriate to case-control data will be covered, including stratified and regression methods. The course will be based on classroom lectures and small group discussions of exercises.


  • To understand the main case-control study designs and understand the importance of the type of control group to the parameter estimated by the exposure odds ratio;
  • To recognize the main problems when drawing inferences from results of case-control studies;
  • To learn and apply the main techniques of confounding adjustment and assessment of interactions in case-control studies.

Participant profile

Individuals who aim at conducting case-control studies and/or reviewing published reports of results of case-control studies.